• Respir Physiol Neurobiol · Jun 2014

    Excess ventilation and ventilatory constraints during exercise in patients with chronic obstructive pulmonary disease.

    • Elisabetta Teopompi, Panagiota Tzani, Marina Aiello, Maria Rosaria Gioia, Emilio Marangio, and Alfredo Chetta.
    • Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy.
    • Respir Physiol Neurobiol. 2014 Jun 15; 197: 9-14.

    AbstractWe assessed the relationship between minute ventilation/carbon dioxide output (VE/VCO2) and ventilatory constraints during an incremental cardiopulmonary exercise testing (CPET) in patients with chronic obstructive pulmonary disease (COPD). Slope and intercept of the VE/VCO2 linear relationship, the ratios of inspiratory capacity/total lung capacity (IC/TLC) and of tidal volume (VT) over vital capacity (VTpeak/VC) and IC (VTpeak/IC) and over forced expiratory volume at 1st second (VTpeak/FEV1) at peak of exercise were measured in 52 COPD patients during a CPET. The difference peak-rest in end-tidal pressure of CO2 (PETCO2) was also measured. VE/VCO2 intercept showed a negative correlation with IC/TLC peak (p<0.01) and a positive one with VTpeak/FEV1 (p<0.01) and with PETCO2 peak-rest (p<0.01). VE/VCO2 slope was negatively related to VTpeak/VC, VTpeak/IC and VTpeak/FEV1 (all correlations p<0.05) and to PETCO2 peak-rest (p<0.01). In COPD, VE/VCO2 slope and intercept provide complementary information on the ventilatory limitation to exercise, as assessed by changes in the end-expiratory lung volume and in tidal volume excursion. Copyright © 2014 Elsevier B.V. All rights reserved.

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