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Anesthesia and analgesia · Jun 2018
Activation of Melatonin Receptors by Ramelteon Induces Cardioprotection by Postconditioning in the Rat Heart.
- Martin Stroethoff, Friederike Behmenburg, Kerstin Spittler, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn, and Alexander Mathes.
- From the Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, Germany.
- Anesth. Analg. 2018 Jun 1; 126 (6): 2112-2115.
AbstractActivation of melatonin receptors protects the heart against ischemia-reperfusion injury. Ramelteon, a clinically used drug for insomnia, acts via activation of melatonin receptors. We investigated whether ramelteon induces acute infarct size reduction by postconditioning. Male Wistar rats were randomized to 6 groups. Hearts were treated with melatonin and ramelteon at the beginning of reperfusion. The melatonin receptor inhibitor luzindole was administered with and without melatonin and ramelteon, respectively. Ramelteon reduced infarct size to the same extent as melatonin. Both effects were completely abolished by luzindole. The results show for the first time that ramelteon induces cardioprotection by postconditioning.
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