• Neuron · May 2002

    Respiratory rhythm: an emergent network property?

    • Christopher A Del Negro, Consuelo Morgado-Valle, and Jack L Feldman.
    • Systems Neurobiology Laboratory, Department of Neurobiology, University of California-Los Angeles, Box 95-1763, 90095, USA. delnegro@ucla.edu
    • Neuron. 2002 May 30; 34 (5): 821-30.

    AbstractWe tested the hypothesis that pacemaker neurons generate breathing rhythm in mammals. We monitored respiratory-related motor nerve rhythm in neonatal rodent slice preparations. Blockade of the persistent sodium current (I(NaP)), which was postulated to underlie voltage-dependent bursting in respiratory pacemaker neurons, with riluzole (< or =200 microM) did not alter the frequency of respiratory-related motor output. Yet, in every pacemaker neuron recorded (50/50), bursting was abolished at much lower concentrations of riluzole (< or =20 microM). Thus, eliminating the pacemaker population (our statistics confirm that this population is reduced at least 94%, p < 0.05) does not affect respiratory rhythm. These results suggest that voltage-dependent bursting in pacemaker neurons is not essential for respiratory rhythmogenesis, which may instead be an emergent network property.

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