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Paediatric anaesthesia · Sep 2013
ReviewUnexpected MH deaths without exposure to inhalation anesthetics in pediatric patients.
- Barbara W Brandom and Sheila M Muldoon.
- Department of Anesthesiology, North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. brandombw@anes.upmc.edu
- Paediatr Anaesth. 2013 Sep 1;23(9):851-4.
AbstractChildren, later found to have ryanodine receptor type one variants (RYR1), died without exposure to inhalation anesthetics. Family members with the same RYR1 variants had contracture tests consistent with susceptibility to malignant hyperthermia or in vitro testing showed increased sensitivity to RYR1 agonist.© 2013 John Wiley & Sons Ltd.
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