• Steve J R Coppens, Zoriana Zawodny, Geertrui Dewinter, Arne Neyrinck, Angela Lucia Balocco, and Steffen Rex.
• Department of Anaesthesiology, University Hospitals of the KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Electronic address: steve.coppens@uzleuven.be.
• Best Pract Res Clin Anaesthesiol. 2019 Mar 1; 33 (1): 3-21.

AbstractRegional anesthesia has been advocated as adjunct to a multimodal analgesia regimen. The limited duration of the action of available local anesthetics limits their application. Catheters, perineural or IV adjuvants, or repetition of blocks are modalities available to prolong the analgesic benefit of LRA. All of these approaches have their shortcomings. New extended release local anesthetic formulations may provide time-efficient and longer duration of analgesia with a single injection. Available data on liposomal bupivacaine are promising, and more recently, it has been FDA approved for use in interscalene brachial plexus block but not for other nerve blocks at this time. Several other new formulations and compounds, such as HTX-011, Neosaxitoxin, and SABER-Bupivacaine, are also being developed and tested for their safety and analgesic potential.Copyright © 2019 Elsevier Ltd. All rights reserved.

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