• Arch Intern Med · Jul 1991

    Review

    Sarcoidosis of the nervous system. A clinical approach.

    • O P Sharma and A M Sharma.
    • Sarcoidosis Clinic, Los Angeles County-University of Southern California Medical Center, 90033.
    • Arch Intern Med. 1991 Jul 1; 151 (7): 1317-21.

    AbstractSarcoidosis is a multisystem disorder of unknown cause. The disease is characterized by the presence of noncaseating granulomas in the affected tissue system. Clinically recognizable nervous system involvement occurs in about 10% of patients with sarcoidosis, although the incidence of subclinical neurosarcoidosis is much higher. The disease appears in the differential diagnosis of many infectious and noninfectious neurological syndromes. We have reviewed all aspects of neurosarcoidosis from the point of view of practicing internists, including the clinical manifestations, cerebrospinal fluid and radiographic changes, differential diagnosis, and treatment.

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