• Continuum (Minneap Minn) · Jun 2014

    Review

    Neurosarcoidosis.

    • Jinny O Tavee and Barney J Stern.
    • Continuum (Minneap Minn). 2014 Jun 1; 20 (3 Neurology of Systemic Disease): 545-59.

    Purpose Of ReviewThis article provides an update on the evaluation and treatment of neurosarcoidosis.Recent FindingsThe broad range of clinical manifestations of neurosarcoidosis has recently expanded to include painful small fiber neuropathy. Although definitive diagnosis remains a challenge, fluorodeoxyglucose positron emission tomographic (FDG-PET) scan and high-resolution CT allow for improved detection of systemic sarcoidosis. In addition, endobronchial ultrasound-guided transbronchial needle aspiration provides a less invasive means of tissue confirmation of systemic sarcoidosis than mediastinoscopy. Although not standardized, treatment strategies for neurosarcoidosis now commonly include tumor necrosis factor-α antagonists in combination with corticosteroids and other cytotoxic agents for patients with severe disease.SummaryAdvances in the diagnosis and management of neurosarcoidosis may benefit the patient and clinician faced with this multifaceted disease.

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