• Antonio H Frangieh, Slayman Obeid, Jelena-Rima Ghadri, Yoichi Imori, Fabrizio D'Ascenzo, Marc Kovac, Frank Ruschitzka, Thomas F Lüscher, Firat Duru, Christian Templin, and InterTAK Collaborators.
• Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.
• J Am Heart Assoc. 2016 Jun 13; 5 (6).

BackgroundECG criteria differentiating Takotsubo cardiomyopathy (TTC) from mainly anterior myocardial infarction (MI) have been suggested; however, this was in small patient populations.Methods And ResultsTwelve-lead admission ECGs of consecutive 200 TTC and 200 MI patients were compared in dichotomized groups based on the presence or absence of ST-elevation MI (STEMI versus STE-TTC and non-ST elevation MI versus non ST-elevation-TTC). When comparing STEMI and STE-TTC, ST-elevation in -aVR was characteristic of STE-TTC with a sensitivity/specificity of 43% and 95%, positive predictive value (PPV) 91%, and a negative predictive value (NPV) 62% (P<0.001); when ST-elevation in -aVR is accompanied by ST-elevation in inferior leads, sensitivity/specificity were 14% and 98% (PPV was 89% and NPV 52%) (P=0.001), and 12% and 100% when associated with ST-elevation in anteroseptal leads (PPV 100%, NPV 52%) (P<0.001). On the other hand, STEMI was characterized by ST-elevation in aVR (sensitivity/specificity of 31% and 95% P<0.001, PPV 85% and NPV 59%) and ST-depression in V2-V3-V4 (sensitivity/specificity of 24% and 100% P<0.001, PPV 100% and NPV 76%). When comparing non-ST elevation MI and non ST-elevation-TTC, T-inversion in leads I-aVL-V5-V6 had a sensitivity/specificity of 17% and 97% for non ST-elevation-TTC (PPV 83% and NPV 55%) (P<0.001), and ST-elevation in -aVR with T-inversion in any lead was also specific for non ST-elevation-TTC (sensitivity/specificity of 8% and 100%, PPV 100% and NPV 53%) (P=0.006). In non-ST elevation MI patients, the presence of ST-depression in V2-V3 was specific (sensitivity/specificity of 11% and 99%, PPV 91% and NPV 51%) (P=0.01).ConclusionsECG on admission can differentiate between TTC and acute MI, with high specificity and positive predictive value.Clinical Trial RegistrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT01947621.© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

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