• Drugs Exp Clin Res · Jan 1994

    Comparative Study

    Dextrorphan and dextromethorphan: comparative antitussive effects on guinea pigs.

    • P C Braga, A Fossati, M G Vimercati, R Caputo, and E E Guffanti.
    • Department of Pharmacology, School of Medicine, University of Milan, Italy.
    • Drugs Exp Clin Res. 1994 Jan 1; 20 (5): 199-203.

    AbstractDextromethorphan, after administration, is rapidly and extensively transformed into dextrorphan. The aim of this study was to compare the cough-suppressing activity of 6, 12, 24, 48 mg/kg, i.p., of dextrorphan (dextro rotatory isomer of racemorphan) with that of dextromethorphan, using the model of citric acid-induced coughing in the unanaesthetized, unrestrained guinea pig. A significant dose-effect relationship of dextrorphan in reducing citric acid-induced cough was observed. This effect was comparable with that of dextromethorphan. However, at 48 mg/kg, i.p., dextromethorphan had a toxic effect while dextrorphan did not. Because dextrorphan is the major metabolite of dextromethorphan and has antitussive activity comparable to that of dextromethorphan, clinical use of dextrorphan is suggested.

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