• Young-Eun Jang, Eun-Hee Kim, Ji-Hyun Lee, Hee-Soo Kim, and Jin-Tae Kim.
• From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital (Y-EJ, E-HK, J-HL) and Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea (H-SK, J-TK).
• Eur J Anaesthesiol. 2019 Oct 1; 36 (10): 738-744.

BackgroundCannulation of the radial artery is challenging to perform in neonates and infants because of the small vessel size.ObjectiveTo compare guidewire-assisted with direct radial artery cannulation in neonates and infants.DesignA randomised controlled study.SettingA tertiary university hospital from 7 August 2017 to 4 July 2018.PatientsNinety neonates and infants who required radial artery cannulation during general anaesthesia.InterventionsAll patients were allocated randomly into the guidewire group (guidewire-assisted cannulation, n=45) or control group (direct cannulation, n=45). Radial artery cannulation was performed under general anaesthesia. The contralateral radial artery was used if the arterial cannulation was not successful within two attempts. After the second failure in the contralateral radial artery, the case was considered a failure.Main Outcome MeasuresThe primary outcome was the first-attempt success rate of radial artery cannulation. The secondary outcomes included the overall success rate, overall procedure time, number of attempts and use of the contralateral radial artery for radial artery cannulation.ResultsThe guidewire group showed a higher first-attempt success rate [76 vs. 56%; P = 0.046; odds ratio (OR) 2.47, 95% confidence interval (CI) of odds 1.01 to 6.08] and overall success rate (96 vs. 76%; P = 0.007; OR 6.96; 95% CI 1.44 to 33.52) than the control group. The overall procedure time was not significantly different between the guidewire group (median [IQR] 36 [28.0 to 70.5] s) and control group (98 [23.5 to 465.0] s; P = 0.400). There was no difference in the median number of attempts between the two groups (P = 0.454). However, use of the contralateral radial artery was significantly lower in the guidewire group (17.8%) than in the control group (40%; P = 0.020; OR 0.324, 95% CI 0.12 to 0.86). Kaplan-Meier analysis of the overall procedure time to successful radial artery cannulation showed that the overall success rate was significantly higher in the guidewire group than in the control group (P = 0.019).ConclusionFor radial artery cannulation in neonates and infants, guidewire-assisted radial artery cannulation showed superiority over the direct technique in terms of first-attempt success rate and overall success rate without delaying the procedure time.Trial RegistrationClinicaltrials.gov (identifier: NCT03217019).

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