• Trends in immunology · Mar 2015

    Review

    Lung ILC2s link innate and adaptive responses in allergic inflammation.

    • Itziar Martinez-Gonzalez, Catherine A Steer, and Fumio Takei.
    • Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.
    • Trends Immunol. 2015 Mar 1; 36 (3): 189-95.

    AbstractHow allergens trigger the T helper 2 (Th2) response that characterizes allergic lung inflammation is not well understood. Epithelium-derived alarmins released after an allergen encounter activate the innate immune system, including group 2 innate lymphoid cells (ILC2s) which produce the type 2 interleukins IL-5 and IL-13. It has been recently shown that ILC2-derived cytokines are responsible not only for the innate responses underlying allergic inflammation but also for the initiation of the adaptive Th2 response. We review the role of lung ILC2s in the development of allergic inflammation and, in the context of recent findings, propose a common pathway wherein ILC2s, activated by the epithelium-derived cytokine IL-33, link the innate and the adaptive responses after allergen encounter in the lung. Copyright © 2015 Elsevier Ltd. All rights reserved.

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