• Am J Emerg Med · Sep 2018

    Randomized Controlled Trial

    Impact of intestinal mannitol on hyperammonemia, oxidative stress and severity of hepatic encephalopathy in the ED.

    • Daniel H Montes-Cortés, José L Novelo-Del Valle, Ivonne M Olivares-Corichi, José V Rosas-Barrientos, Luis J Jara, and María Pilar Cruz-Domínguez.
    • Urgencias Adultos. Hospital General, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social, 02990 Ciudad de México, Mexico; Coordinación de Enseñanza e Investigación. Hospital Regional 1° de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, 07760 Ciudad de México, Mexico.
    • Am J Emerg Med. 2018 Sep 1; 36 (9): 1570-1576.

    AbstractHyperammonemia results from hepatic inability to remove nitrogenous products generated by protein metabolism of intestinal microbiota, which leads to hepatic encephalopathy (HE) in chronic liver disease (CLD). In ammonium neurotoxicity, oxidative stress (OxS) plays a pathogenic role. Our objective was to evaluate if intestinal mannitol is as effective and safe as conventional treatment for diminishing hyperammonemia, OxS, and HE in patients with CLD.Copyright © 2018 Elsevier Inc. All rights reserved.

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