• Dermatologic therapy · Sep 2018

    Review Case Reports

    Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine.

    • Nicholas Bradford Castner, Jessica Crabbe Harris, and Kiran Motaparthi.
    • Department of Dermatology, University of South Florida Morsani College of Medicine, Tampa, Florida.
    • Dermatol Ther. 2018 Sep 1; 31 (5): e12660.

    AbstractAcute generalized exanthematous pustulosis most often manifests 1-2 days following exposure to a characteristic drug, such as aminopenicillins, calcium-channel blockers, or terbinafine. Recovery is usually rapid following drug withdrawal, and systemic corticosteroids represent the historic treatment of choice. Herein, acute generalized exanthematous pustulosis incited by hydroxychloroquine is briefly reviewed: a prolonged latency and recalcitrance to corticosteroids are noteworthy. In this unique context, cyclosporine tapered over several months is an effective therapeutic option.© 2018 Wiley Periodicals, Inc.

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