• Seiichi Miwa, Takafumi Suda, Sumihito Morita, Naoki Inui, Jun Sato, and Kingo Chida.
• Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. hirosei@za.tnc.ne.jp
• Respirology. 2007 Sep 1; 12 (5): 744-8.

Background And ObjectivesA variety of markers, such as serum angiotensin-converting enzyme (sACE) and CXR have been used to evaluate the disease activity and progression of sarcoidosis. There are patients who have developed cardiac involvement several years after the initial diagnosis despite stable or decreased disease activity. This study clarified the clinical characteristics of those patients.MethodsA total of 141 consecutive patients treated for sarcoidosis were studied. Heterochronic cardiac sarcoidosis was defined as the sudden onset of cardiac manifestations more than 2 years after the initial diagnosis despite stable lung disease and normal sACE levels.ResultsOf the patients studied four showed heterochronic cardiac involvement. These patients were all middle-aged women (mean age, 50.5 years) with multiple organ involvement. The time period from the initial diagnosis of sarcoidosis to the onset of cardiac involvement ranged from 3 to 8 years, with a mean duration of 5.2 years. All patients showed fatal conduction abnormalities.ConclusionsMiddle-aged women with multiple organ involvement of sarcoidosis are at risk of developing cardiac sarcoidosis.

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