• Larissa Henze, Axel Sckell, Alexander März, and Christian Junghanß.
• Zentrum für Innere Medizin, Medizinische Klinik III, Klinik für Hämatologie, Onkologie, Palliativmedizin, Universitätsmedizin Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Deutschland. onkologie@med.uni-rostock.de.
• Unfallchirurg. 2019 Aug 1; 122 (8): 633-645.

AbstractAs the population gets older the prevalence of atrial fibrillation and venous thromboembolism also increases. Therefore, more patients require anticoagulation and currently direct oral anticoagulants (DOAC), such as dabigatran etexilate, apixaban, rivaroxaban and edoxaban are preferred to vitamin K antagonists (VKA), mainly because of the more favorable risk-benefit profile with respect to bleeding. Older patients in particular frequently present at the accident and emergency department due to falls and an increased risk of fractures. The perioperative management of these patients who are treated with DOACs is a challenge in the clinical routine and needs special consideration. This article discusses these issues in an interdisciplinary approach and develops strategies for the perioperative management of patients treated with DOACs and undergoing trauma or orthopedic surgery.

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