• The lancet oncology · Aug 2019

    Review

    Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy.

    • Eric Deutsch, Cyrus Chargari, Lorenzo Galluzzi, and Guido Kroemer.
    • Department of Radiation Oncology, Gustave Roussy Comprehensive Cancer Center, Villejuif, France; Faculté de Médecine, Université Paris Sud/Paris Saclay, Paris, France; INSERM, U1030, Paris, France.
    • Lancet Oncol. 2019 Aug 1; 20 (8): e452-e463.

    AbstractImmunotherapy is radically changing the clinical management of patients affected by an increasingly wide array of tumours. However, not all patients achieve long-term clinical benefits from immunotherapy as a standalone treatment, calling for the development of regimens that combine various interventions. Radiotherapy stands out as a particularly promising candidate in this setting, not only because of its established safety profile, but also because radiotherapy has the potential ability to mediate robust immunostimulatory effects that could synergise with immunotherapy in systemic tumour control. However, optimal radioimmunotherapy regimens might call for the redefinition of conventional radiotherapy doses and fractionation schedules. In this Series paper, we discuss current approaches to improve the efficacy and reduce the toxicity of radioimmunotherapy for the management of cancer.Copyright © 2019 Elsevier Ltd. All rights reserved.

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