• Sergey Motov, Aidin Masoudi, Jefferson Drapkin, Cecily Sotomayor, Samuel Kim, Mahlaqa Butt, Antonios Likourezos, Catsim Fassassi, Rukhsana Hossain, Jason Brady, Nechama Rothberger, Peter Flom, and John Marshall.
• Department of Emergency Medicine, Maimonides Medical Center, Brooklyn, NY.
• Ann Emerg Med. 2019 Oct 1; 74 (4): 530-537.

Study ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) are used extensively for the management of acute pain, with ibuprofen being one of the most frequently used oral analgesics in the emergency department (ED). We compare the analgesic efficacy of oral ibuprofen at 3 different doses for adult ED patients with acute pain.MethodsThis was a randomized, double-blind trial comparing analgesic efficacy of 3 doses of oral ibuprofen (400, 600, and 800 mg) in adult ED patients with acute painful conditions. Primary outcome included difference in pain scores between the 3 groups at 60 minutes.ResultsWe enrolled 225 subjects (75 per group). The difference in mean pain scores at 60 minutes between the 400- and 600-mg groups was -0.14 (95% confidence interval [CI] -0.67 to 0.39); between the 400- and 800-mg groups, 0.14 (95% CI -0.65 to 0.37); and between the 600- and 800-mg groups, 0.00 (95% CI -0.47 to 0.47). Reductions in pain scores from baseline to 60 minutes were similar for all subjects in each of the 3 groups. No adverse events occurred in any group.ConclusionOral ibuprofen administered at doses of 400, 600, and 800 mg has similar analgesic efficacy for short-term pain relief in adult patients presenting to the ED with acute pain.Copyright © 2019 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

19 keywords...

hide…