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- Yi-Chieh Hung, Nasser Mohammed, Kathryn N Kearns, Ching-Jen Chen, Robert M Starke, Hideyuki Kano, John Lee, David Mathieu, Anthony M Kaufmann, Wei Gang Wang, Inga S Grills, Christopher P Cifarelli, John Vargo, Tomas Chytka, Ladislava Janouskova, Caleb E Feliciano, Rafael Rodriguez-Mercado, L Dade Lunsford, and Jason P Sheehan.
- Division of Neurosurgery, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
- Neurosurgery. 2020 May 1; 86 (5): 676-684.
BackgroundDural arteriovenous fistulas (DAVFs) can be categorized based on location.ObjectiveTo compare stereotactic radiosurgery (SRS) outcomes between cavernous sinus (CS) and non-CS DAVFs and to identify respective outcome predictors.MethodsThis is a retrospective study of DAVFs treated with SRS between 1988 and 2016 at 10 institutions. Patients' variables, DAVF characters, and SRS parameters were included for analyses. Favorable clinical outcome was defined as angiography-confirmed obliteration without radiological radiation-induced changes (RIC) or post-SRS hemorrhage. Other outcomes were DAVFs obliteration and adverse events (including RIC, symptomatic RIC, and post-SRS hemorrhage).ResultsThe overall study cohort comprised 131 patients, including 20 patients with CS DAVFs (15%) and 111 patients with non-CS DAVFs (85%). Rates of favorable clinical outcome were comparable between the 2 groups (45% vs 37%, P = .824). Obliteration rate after SRS was higher in the CS DAVFs group, even adjusted for baseline difference (OR = 4.189, P = .044). Predictors of favorable clinical outcome included higher maximum dose (P = .014) for CS DAVFs. Symptomatic improvement was associated with obliteration in non-CS DAVFs (P = .005), but symptoms improved regardless of whether obliteration was confirmed in CS DAVFs. Non-CS DAVFs patients with adverse events after SRS were more likely to be male (P = .020), multiple arterial feeding fistulas (P = .018), and lower maximum dose (P = .041).ConclusionAfter SRS, CS DAVFs are more likely to obliterate than non-CS ones. Because these 2 groups have different total predictors for clinical and radiologic outcomes after SRS, they should be considered as different entities.Copyright © 2019 by the Congress of Neurological Surgeons.
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