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- Fanglin Lu, Kei Inoue, Jungo Kato, Shizuka Minamishima, and Hiroshi Morisaki.
- Keio University Graduate School of Medicine Doctoral Programs, Tokyo, Japan.
- Crit Care. 2019 Aug 2; 23 (1): 269.
AbstractLipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.
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