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Am. J. Respir. Crit. Care Med. · Jun 2018
Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13.
- Maha Zohra Ladjemi, Delphine Gras, Sébastien Dupasquier, Bruno Detry, Marylène Lecocq, Céline Garulli, Chantal Fregimilicka, Caroline Bouzin, Sophie Gohy, Pascal Chanez, and Charles Pilette.
- 1 Pôle de Pneumologie, ORL, et Dermatologie and.
- Am. J. Respir. Crit. Care Med. 2018 Jun 1; 197 (11): 1396-1409.
RationaleAsthma is associated with increased lung IgE production, but whether the secretory IgA system is affected in this disease remains unknown.ObjectivesWe explored mucosal IgA transport in human asthma and its potential regulation by T-helper cell type 2 inflammation.MethodsBronchial biopsies from asthma and control subjects were assayed for bronchial epithelial polymeric immunoglobulin receptor (pIgR) expression and correlated to T-helper cell type 2 biomarkers. Bronchial epithelium reconstituted in vitro from these subjects, on culture in air-liquid interface, was assayed for pIgR expression and regulation by IL-4/IL-13.Measurements And Main ResultsDownregulation of pIgR protein was observed in the bronchial epithelium from patients with asthma (P = 0.0002 vs. control subjects). This epithelial defect was not observed ex vivo in the cultured epithelium from patients with asthma. Exogenous IL-13 and IL-4 could inhibit pIgR expression and IgA transcytosis. Mechanistic experiments showed that autocrine transforming growth factor-β mediates the IL-4/IL-13 effect on the pIgR, with a partial contribution of upregulated transforming growth factor-α/epidermal growth factor receptor.ConclusionsThis study shows impaired bronchial epithelial pIgR expression in asthma, presumably affecting secretory IgA-mediated frontline defense as a result of type 2 immune activation of the transforming growth factor pathway.
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