• Orthop. Clin. North Am. · Apr 2017

    Effect of Tranexamic Acid on Transfusion Rates Following Total Joint Arthroplasty: A Cost and Comparative Effectiveness Analysis.

    • Perry J Evangelista, Michael W Aversano, Emmanuel Koli, Lorraine Hutzler, Ifeoma Inneh, Joseph Bosco, and Richard Iorio.
    • Department of Orthopaedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Centre, New York University Hospital for Joint Diseases, 301 E 17th Street, 14th Floor, New York, NY 10003, New York. Electronic address: perry.evangelista@nyumc.org.
    • Orthop. Clin. North Am. 2017 Apr 1; 48 (2): 109-115.

    AbstractTranexamic acid (TXA) is used to reduce blood loss in orthopedic total joint arthroplasty (TJA). This study evaluates the effectiveness of TXA in reducing transfusions and hospital cost in TJA. Participants undergoing elective TJA were stratified into 2 cohorts: those not receiving and those receiving intravenous TXA. TXA decreased total hip arthroplasty (THA) transfusions from 22.7% to 11.9%, and total knee arthroplasty (TKA) from 19.4% to 7.0%. The average direct hospital cost reduction for THA and TKA was $3083 and $2582, respectively. Implementation of a TJA TXA protocol significantly reduced transfusions in a safe and cost-effective manner.Copyright © 2016 Elsevier Inc. All rights reserved.

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