• Eur. J. Pharmacol. · Jul 1980

    Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs.

    • F Casamenti, C Bianchi, L Beani, and G Pepeu.
    • Eur. J. Pharmacol. 1980 Jul 25; 65 (2-3): 279-84.

    AbstractThe effect of haloperidol, pimozide and amphetamine on acetylcholine (ACh) output from the cerebral cortex was investigated in unanaesthetized, freely moving and urethane-anaesthetized rats and guinea pigs. Haloperidol (1 mg/kg i.p.) decreased ACh output only in the anaesthetized rats and increased it only in unanaesthetized guinea pigs. Pimozide (1 mg/kg i.p.) stimulated ACh output in unanaesthetized rats and guinea pigs and anaesthetized guinea pigs, but not in anaesthetized rats. Amphetamine (1 mg/kg i.p.) in all cases, stimulated ACh output. In rats with a septal lesion, the effect of amphetamine on ACh output was suppressed but that of pimozide was still present.

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