• Pediatr Crit Care Me · Aug 2019

    Observational Study

    Association of Organ Dysfunction Scores and Functional Outcomes Following Pediatric Critical Illness.

    • Travis J Matics, Neethi P Pinto, and L Nelson Sanchez-Pinto.
    • Department of Pediatrics, The University of Chicago, Chicago, IL.
    • Pediatr Crit Care Me. 2019 Aug 1; 20 (8): 722-727.

    ObjectivesShort-term and long-term morbidity and mortality are common following pediatric critical illness. Severe organ dysfunction is associated with significant in-hospital mortality in critically ill children; however, the performance of pediatric organ dysfunction scores as predictors of functional outcomes after critical illness has not been previously assessed.DesignSecondary analysis of a prospective observational cohort.SettingA multidisciplinary, tertiary, academic PICU.PatientsPatients less than or equal to 18 years old admitted between June 2012 and August 2012.InterventionsNone.Measurements And Main ResultsThe maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during admission were calculated. The Functional Status Scale score was obtained at baseline, 6 months and 3 years following discharge. New morbidity was defined as a change in Functional Status Scale greater than or equal to 3 points from baseline. The performance of organ dysfunction scores at discriminating new morbidity or mortality at 6 months and 3 years was measured using the area under the curve. Seventy-three patients met inclusion criteria. Fourteen percent had new morbidity or mortality at 6 months and 23% at 3 years. The performance of the maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores at discriminating new morbidity or mortality was excellent at 6 months (areas under the curves 0.9 and 0.88, respectively) and good at 3 years (0.82 and 0.79, respectively).ConclusionsSeverity of organ dysfunction is associated with longitudinal change in functional status and short-term and long-term development of new morbidity and mortality. Maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during critical illness have good to excellent performance at predicting new morbidity or mortality up to 3 years after critical illness. Use of these pediatric organ dysfunction scores may be helpful for prognostication of longitudinal functional outcomes in critically ill children.

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