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Review Case Reports
Exon 8-17 deletions of SPAST in a Chinese family with hereditary spastic paraplegia: a case report and literature review.
- Kang Wang and Guohua Zhao.
- Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, China.
- J. Neurol. Sci. 2015 Oct 15; 357 (1-2): 282-4.
AbstractHereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurodegenerative disorders. SPG4 is the most common autosomal dominant form of HSP subtypes and is caused by mutations of the SPAST gene. Here we reported a Chinese family with HSP caused by deletion of exons 8-17 of the SPAST gene and reviewed the clinical phenotypes of patients with exon deletion that were reported in literatures. The patients with deletions of exons in the SPAST gene showed pure HSP, and the age at onset showed interfamily and intrafamily variations. This study suggests that exon deletion should be examined routinely in patients who are clinically diagnosed with HSP.Copyright © 2015 Elsevier B.V. All rights reserved.
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