• The Journal of infection · Mar 2012

    Multicenter Study

    Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza.

    • Emili Diaz, Ignacio Martin-Loeches, Laura Canadell, Loreto Vidaur, David Suarez, Lorenzo Socias, Angel Estella, Bernardo Gil Rueda, José Eugenio Guerrero, Montserrat Valverdú-Vidal, Juan Carlos Vergara, María Jesús López-Pueyo, Mónica Magret, Teresa Recio, Diego López, Jordi Rello, Alejandro Rodriguez, and H1N1 SEMICYUC-CIBERES-REIPI Working Group (GETGAG).
    • Critical Care Department, Hospital Sant Joan Despí Moisès Broggi, Jacint Verdaguer, 90, 08970 Sant Joan Despí, Barcelona, CIBERES, IISPV, Spain. emilio.diaz.santos@gmail.com
    • J. Infect. 2012 Mar 1; 64 (3): 311-8.

    ObjectiveDuring the first pandemic, some patients with pandemic (H1N1) 2009 influenza were treated with corticosteroids. The objective of this study was to assess the effect on survival of corticosteroid therapy in patients with pandemic (H1N1) 2009 influenza.MethodsProspective, observational, multicenter study performed in 148 ICU. Data were recorded in the GTEI/SEMICYUC registry. Adult patients with pandemic (H1N1) 2009 influenza confirmed by rt-PCR were included in the analysis. Database records specified corticosteroid type and reason for corticosteroid treatment.Results372 patients with the diagnosis of primary viral pneumonia and completed outcomes treated in an ICU were included in the database. Mechanical ventilation was used in 70.2% of the patients. 136 (36.6%) patients received corticosteroids after a diagnosis of primary viral pneumonia. Obesity (35.6% vs 47.8% p = 0.021) and asthma (7.6% vs 15.4% p = 0.018), were more frequent in the group treated with corticosteroids. A Cox regression analysis adjusted for severity and potential confounding factors found that the use of corticosteroid therapy was not significantly associated with mortality (HR = 1.06, 95% CI 0.626-1.801; p = 0.825).ConclusionsCorticosteroid therapy in a selected group of patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza does not improve survival.Copyright © 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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