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Clin. Pharmacol. Ther. · Aug 2015
ReviewCardiovascular Risk in Diabetes Mellitus: Complication of the Disease or of Antihyperglycemic Medications.
- C A Alvarez, I Lingvay, V Vuylsteke, R L Koffarnus, and D K McGuire.
- Texas Tech University Health Sciences Center, Dallas, Texas, University of Texas Southwestern, Dallas, Texas, USA.
- Clin. Pharmacol. Ther. 2015 Aug 1; 98 (2): 145-61.
AbstractCardiovascular disease is the principal complication and the leading cause of death for patients with diabetes (DM). The efficacy of antihyperglycemic treatments on cardiovascular disease risk remains uncertain. Cardiovascular risk factors are affected by antihyperglycemic medications, as are many intermediate markers of cardiovascular disease. Here we summarize the evidence assessing the cardiovascular effects of antihyperglycemic medications with regard to risk factors, intermediate markers of disease, and clinical outcomes. © 2015 American Society for Clinical Pharmacology and Therapeutics.
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