• Mult. Scler. · Sep 2011

    Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability.

    • Stefan D Roosendaal, Kerstin Bendfeldt, Hugo Vrenken, Chris H Polman, Stefan Borgwardt, Ernst W Radue, Ludwig Kappos, Daniel Pelletier, Stephen L Hauser, Paul M Matthews, Frederik Barkhof, and Jeroen J G Geurts.
    • Department of Radiology, VU University Medical Centre, Amsterdam, The Netherlands. s.roosendaal@vumc.nl
    • Mult. Scler. 2011 Sep 1; 17 (9): 1098-106.

    BackgroundAlthough grey matter damage in multiple sclerosis is currently recognized, determinants of grey matter volume and its relationship with disability are not yet clear.ObjectivesThe objectives of the study were to measure grey and white matter volumes across different disease phenotypes; identify MRI parameters associated with grey matter volume; and study grey and white matter volume as explanatory variables for clinical impairment.MethodsThis is a cross-sectional study in which MRI data of 95 clinically isolated syndrome, 657 relapsing-remitting, 125 secondary-progressive and 50 primary-progressive multiple sclerosis patients from three centres were acquired. Grey and white matter volumes were determined, together with T2 and T1 lesion volumes. Physical disability was assessed with the Expanded Disability Status Scale, cognitive impairment with the Paced Auditory Serial Addition Task. Data were analysed using multiple regression.ResultsGrey matter volume was lower in relapsing-remitting patients (mean [SD]: 0.80 [0.05] L) than in clinically isolated syndrome patients (0.82 [0.05] L), and even greater relative atrophy was found in secondary-progressive patients (0.77 [0.05] L). In contrast, white matter volume in secondary-progressive patients was comparable to that in relapsing-remitting patients. Grey matter volume was the strongest independent predictor of physical disability and cognitive impairment, and was associated with both T2 and T1 lesion volume.ConclusionsOur findings show that grey matter volume is lower in secondary-progressive than in relapsing-remitting disease. Grey matter volume explained physical and cognitive impairment better than white matter volume, and is itself associated with T2 and T1 lesion volume.

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