• Jung-Chun Lin, Chin-Sheng Lin, Chin-Wang Hsu, Cheng-Li Lin, and Chia-Hung Kao.
• *Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; †Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; ‡Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; §Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; ‖Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; ¶College of Medicine, China Medical University, Taichung, Taiwan; **Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; and ††Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
• Inflamm. Bowel Dis. 2016 May 1; 22 (5): 1049-55.

ObjectivesInflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that chronic systemic inflammation increases the risk of Parkinson's disease (PD). This study examined the effects of IBD on the development of PD.MethodsIn a nationwide population-based cohort of 23.22 million insured residents of Taiwan aged ≥ 20 years, we compared people diagnosed with IBD during 2000 to 2011 (n = 8373) with IBD-free individuals. Patients with PD were identified in the National Health Insurance Research Database. Using univariable and multivariable Cox proportion hazard regression models, we estimated the adjusted hazard ratio (aHR) for PD with a 95% confidence interval (CI) with adjustment for age, sex, and comorbidities.ResultsIn the cohort, IBD was associated with an increased incidence of PD (crude hazard ratio = 1.43, 95% CI = 1.15-1.79). The risk was highest among individuals with Crohn's disease (aHR = 1.40, 95% CI = 1.11-1.77). In the multivariable model, the risk of PD was increased for men (aHR = 1.28, 95% CI = 1.05-1.56) and higher for patients with hypertension (aHR = 1.72, 95% CI = 1.33-2.24), coronary artery disease (aHR = 1.31, 95% CI = 1.04-1.66), or depression (aHR = 2.51, 95% CI = 1.82-3.46).ConclusionsWe suggest that IBD is associated with an increased risk of PD. Patients with IBD should be aware of the potential risk for PD development.

19 keywords...

hide…