• Huiying Zhao, Shuguang Yang, Huixia Wang, Hua Zhang, and Youzhong An.
• Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China. Electronic address: zhaohuiying109@sina.com.
• J Crit Care. 2019 Dec 1; 54: 136-144.

PurposeTo identify the impact of non-opioid analgesics as adjuvants to opioid on opioid consumption and its side effects, as well as the analgesic effectiveness in adult patients in the ICU.MethodsOnly randomized clinical trials using non-opioid analgesics for analgesia in the ICU were included. Pooled analyses with 95% CI were determined.ResultsTwelve studies (mainly surgical and Guillain-Barre syndrome patients) were included. Non-opioid analgesics as adjuvants to opioid were associated with a significant reduction in the consumption of opioids when compared with opioid use alone at Day 1 (MD -15.40; 95% CI -22.41 to -8.39; P < .001) and Day 2 (MD -22.93; 95% CI -27.70 to -18.16; P < .001). Non-opioid analgesics as adjuvants to opioid were associated with a significantly lower incidence of nausea and vomiting when compared with opioid use alone (RR 0.46; 95% CI 0.30 to 0.68; P < .001). Non-opioid analgesics as adjuvants to opioid significantly decreased the pain score at Day 1 (MD -0.68; 95% CI -1.28 to -0.08; P = .03) and Day 2 (MD -1.36; 95% CI -2.47 to -0.24; P = .02).ConclusionsNon-opioid analgesics as adjuvants to opioid reduced the consumption and the side effects of opioids in adult surgical and Guillain-Barre syndrome patients in the ICU.Trial Review RegistrationPROSPERO international prospective register of systematic reviews on January 23, 2017, registration number CRD42017055768.Copyright © 2019. Published by Elsevier Inc.

22 keywords...

hide…