• Jerry Y Chao, Alan D Legatt, Elissa G Yozawitz, David C Adams, Ellise S Delphin, and Shlomo Shinnar.
• From the *Department of Anesthesiology †The Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience ‡The Saul R. Korey Department of Neurology, Department of Pediatrics §The Saul R. Korey Department of Neurology, Department of Pediatrics, Department of Epidemiology & Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
• Anesth. Analg. 2020 Jun 1; 130 (6): e161e164e161-e164.

AbstractSeizures and interictal epileptiform discharges (IEDs) have been described during sevoflurane. We prospectively estimated their incidence in 54 otherwise neurologically healthy infants by obtaining the full-head video electroencephalogram (EEG). No infants had clinical seizures, but 1 had an electrographic seizure; 3 others had focal IEDs (7.4%; 95% confidence interval [CI], 2.1%-17.9%). We detected no differences in demographic or clinical characteristics between normal and abnormal EEG groups. Diffuse slowing was the most common initial EEG change followed by fast (α, β) activity in all head leads. Larger studies with more statistical power are needed to further investigate the hypotheses generated with this research.

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