• Am J Emerg Med · Jan 1994

    Case Reports

    Severe low back pain secondary to acute interstitial nephritis following administration of ranitidine.

    • D J Karras.
    • Emergency Medicine Section, Temple University School of Medicine, Philadelphia, PA 19140.
    • Am J Emerg Med. 1994 Jan 1; 12 (1): 67-8.

    AbstractAcute interstitial nephritis is a disease characterized by renal inflammation and is thought to be secondary to a hypersensitivity reaction. Although the causes of acute interstitial nephritis are numerous, adverse reactions to many common drugs, particularly antibiotics and nonsteroidal anti-inflammatory agents, are important etiological factors. Acute interstitial nephritis has many clinical manifestations, most notably fever and rash. Flank pain is an uncommon presentation. A case of acute, severe, low-back pain and rash in a healthy woman found to be secondary to acute interstitial nephritis is reported. The etiology of acute interstitial nephritis in this patient's case is suspected to be ranitidine (Zantac; Glaxo Pharmaceuticals, Research Triangle Park, NC), which has not been previously associated with this syndrome.

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