Sequential treatment with ipilimumab and BRAF inhibitors in

Cancer investigation · May 2014

Multicenter Study

Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian cohort of the ipilimumab expanded access program.

Of 93 patients with pretreated, BRAF(V600) mutation-positive advanced melanoma who received vemurafenib or dabrafenib before (n = 45) or after (n = 48) treatment with ipilimumab 3 mg/kg, median overall survival (mOS) from first treatment was 9.9 and 14.5 months, respectively. Among patients treated with a BRAF inhibitor first, mOS from the end of BRAF inhibition was 1.2 months for those who did not complete ipilimumab treatment as per protocol, compared with 12.7 months for those who did (p < .001). Prospective, randomized studies are required to determine the optimal sequencing of ipilimumab and BRAF inhibitors in patients with BRAF-mutated metastatic melanoma.

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- Paolo Antonio Ascierto, Ester Simeone, Vanna Chiarion Sileni, Michele Del Vecchio, Paolo Marchetti, Cappellini Gian Carlo Antonini GC, Ruggero Ridolfi, Francesco de Rosa, Francesco Cognetti, Virginia Ferraresi, Alessandro Testori, Paola Queirolo, Maria Grazia Bernengo, Michele Guida, Luca Galli, Mario Mandalà, Carolina Cimminiello, Gaetana Rinaldi, Fabrizio Carnevale-Schianca, and Michele Maio.
- Melanoma, Cancer Immunotherapy, and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", Naples, Italy,1.
- Cancer Invest. 2014 May 1; 32 (4): 144-9.
AbstractOf 93 patients with pretreated, BRAF(V600) mutation-positive advanced melanoma who received vemurafenib or dabrafenib before (n = 45) or after (n = 48) treatment with ipilimumab 3 mg/kg, median overall survival (mOS) from first treatment was 9.9 and 14.5 months, respectively. Among patients treated with a BRAF inhibitor first, mOS from the end of BRAF inhibition was 1.2 months for those who did not complete ipilimumab treatment as per protocol, compared with 12.7 months for those who did (p < .001). Prospective, randomized studies are required to determine the optimal sequencing of ipilimumab and BRAF inhibitors in patients with BRAF-mutated metastatic melanoma.

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Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian cohort of the ipilimumab expanded access program.

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