• J. Cutan. Pathol. · Jan 2018

    Case Reports

    Lupus-like cutaneous reaction following pembrolizumab: An immune-related adverse event associated with anti-PD-1 therapy.

    • Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, and Emily Y Chu.
    • Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    • J. Cutan. Pathol. 2018 Jan 1; 45 (1): 74-77.

    AbstractPD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy.© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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