• Ates Duman, Ayse Saide Sahin, Kismet Esra Atalik, Cemile öZtin ögün, Hasan Basri Ulusoy, Kadir Durgut, and Selmin öKesli.
• Department of Anesthesiology and Intensive Care, University of Selcuk, Konya, Turkey. atesduman@hotmail.com
• J. Cardiothorac. Vasc. Anesth. 2003 Aug 1; 17 (4): 465-9.

ObjectiveTo determine the myocardial and vascular effects of remifentanil and fentanyl in human atria and saphenous veins.DesignIn vitro, prospective with repeated measures.SettingUniversity research laboratory.InterventionsThe direct effects of remifentanil and fentanyl on the electrical stimulation-induced contraction of nonfailing human atrium and saphenous veins contracted with 5-hydroxytryptamine were studied.Measurements And Main ResultsIn human atrial trabeculae, cumulative (10(-9)-10(-5) mol/L) added remifentanil had no effect on contractile force, compared with untreated muscles (p > 0.05). The force of contraction was significantly less than control values with concentrations of fentanyl ranging from 10(-8) to 10(-5) mol/L (p < 0.05). At the highest concentration (10(-5) mol/L), the inhibition by fentanyl of the electrical stimulation-induced contraction was 40.6% +/- 6.32%. In human saphenous vein strips preconstricted with 5-hydroxytryptamine, remifentanil (10(-8)-10(-5) mol/L) and fentanyl (10(-8)-10(-5) mol/L) produced "concentration-dependent" relaxation when compared with the control contraction value (p < 0.05). The IC(50) was similar with remifentanil and fentanyl and the E(max) of fentanyl was significantly higher than remifentanil (p < 0.05). The venodilatory effects of remifentanil and fentanyl were similar on veins with or without endothelium (p > 0.05).ConclusionsRemifentanil has no direct effect on the contraction of myocardium. Fentanyl inhibits the electrical stimulation-induced contraction in human right atrial muscles in vitro. Remifentanil and fentanyl produce "concentration-dependent" relaxation in human saphenous vein strips independent from the endothelium.

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