• Anesthesia and analgesia · May 1991

    Randomized Controlled Trial Clinical Trial

    Pentamorphone for management of postoperative pain.

    • H Y Wong, R K Parker, R Fragen, and P F White.
    • Department of Anesthesia, Northwesten University Medical School, Chicago, Illinois 60611.
    • Anesth. Analg. 1991 May 1; 72 (5): 656-60.

    AbstractThe efficacy, duration, and safety of the synthetic opioid pentamorphone in the treatment of acute postoperative pain were evaluated in a randomized, double-blind study of 72 patients given 0.08, 0.16, or 0.24 micrograms/kg of pentamorphone or a placebo intravenously in the recovery room after major abdominal or orthopedic surgery. Only patients given 0.24 micrograms/kg of pentamorphone experienced decreased pain intensity and increased sedation, both transient in duration. Although the two higher doses of pentamorphone delayed the patient's request for supplemental morphine, the total amount of morphine required within the first hour was not different between treatments. No acute cardiorespiratory changes were observed. Pentamorphone (0.08-0.24 micrograms/kg) was ineffective for treating acute postoperative pain after major surgery.

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