• Fen Liu, Qiang Shao, Rong Jiang, Zhenguo Zeng, Yang Liu, Yong Li, Qin Liu, Chengzhi Ding, Ning Zhao, Zhiyong Peng, and Kejian Qian.
• Fen Liu, Zhenguo Zeng, Chengzhi Ding, and Ning Zhao are physicians, Rong Jiang is matron, and Kejian Qian is director, Department of Critical Care Medicine, First Affiliated Hospital of Nanchang University, Nanchang, China. Yang Liu is docimaster in the Department of Bacteriology, Yong Li is a physician in the Department of Oncology, and Qin Liu is a physician in the Department of Respirology, First Affiliated Hospital of Nanchang University. Qiang Shao is a doctoral candidate at Nanchang University and a physician in the Department of Critical Care Medicine at First Affiliated Hospital of Nanchang University. Zhiyong Peng is director, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
• Am. J. Crit. Care. 2019 Sep 1; 28 (5): 370-376.

BackgroundHigh-flow oxygen therapy has been widely adopted, but its use for weaning patients from mechanical ventilation has not been reported.ObjectiveTo evaluate whether high-flow oxygen therapy improves the efficiency of weaning patients from mechanical ventilation.MethodsIn a single-center, prospective study, patients receiving mechanical ventilation were randomly assigned to 1 of 3 groups (T-tube, pressure support ventilation, or high-flow oxygen) during 2-hour spontaneous breathing trials in a 14-day study. Participants were followed up until hospital discharge or death.ResultsOf 268 patients included, 90 were assigned to the T-tube group, 96 to the pressure support ventilation group, and 82 to the high-flow oxygen group. The first-day 2-hour spontaneous breathing trial passing rates were higher in the pressure support ventilation and high-flow oxygen groups than in the T-tube group (P < .05). The time needed to pass the spontaneous breathing trial was less in the pressure support ventilation and high-flow oxygen groups than in the T-tube group (P < .05). The reintubation rate was lower and the successful weaning rate on the first day was higher in the high-flow oxygen group than in the T-tube and pressure support ventilation groups (P < .05). During the 14-day study period, the weaning time was less in the high-flow oxygen group than in the T-tube and pressure support ventilation groups (P < .05).ConclusionHigh-flow oxygen therapy can reduce the time needed to wean patients from mechanical ventilation by shortening the time needed to pass a spontaneous breathing trial and by decreasing the reintubation rate.©2019 American Association of Critical-Care Nurses.

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