• Zinet Asuman Arslan Onuk, Umut Rıza Gündüz, Ümit Koç, Esra Kızılateş, İsmail Gömceli, S Halide Akbaş, and Nurullah Bülbüller.
• Department of Anesthesiology and Reanimation, University of Health Science, Antalya Training and Research Hospital, Antalya-Turkey.
• Ulus Travma Acil Cer. 2019 Sep 1; 25 (5): 440-446.

BackgroundThis prospective randomized study aims to compare outcomes between immediate laparoscopic cholecystectomy (LC) and same admission delayed LC in patients with acute cholecystitis and also to investigate the relation between oxidative stress markers and complication rates in the patients with AC.MethodsThis study included 64 patients with AC who were randomly divided into two groups. Patients in Group 1 (n=32) were immediately administered LC, while in Group 2 (n=32) patients underwent transient LC following medical treatment. All patients were operated on their first hospitalization.ResultsNo statistically significant differences were observed between the groups for the comparison of complications, conversion rates, or operation durations (p>0.05). The length of postoperative hospital stay was found to be significantly shorter in group 1 compared to group 2 (1.75 vs 2.93 days; p=0.024). Only the total antioxidant status result was significantly higher in group 1 (p=0.017), but the finding was not correlated with complications.ConclusionLC for AC was performed during the first admission was found to be safe, even beyond 72 hours following symptom onset. Pre-operative oxidative stress markers did not correlate with the complication rates.

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