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- Gabriel Wardi, Jessica Brice, Matthew Correia, Dennis Liu, Michael Self, and Christopher Tainter.
- Department of Emergency Medicine, University of California at San Diego, San Diego, CA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California at San Diego, San Diego, CA. Electronic address: gwardi@ucsd.edu.
- Ann Emerg Med. 2020 Feb 1; 75 (2): 287-298.
AbstractThe role of lactic acid and its conjugate base, lactate, has evolved during the past decade in the care of patients in the emergency department (ED). A recent national sepsis quality measure has led to increased use of serum lactate in the ED, but many causes for hyperlactatemia exist outside of sepsis. We provide a review of the biology of lactate production and metabolism, the many causes of hyperlactatemia, and evidence on its use as a marker in prognosis and resuscitation. Additionally, we review the evolving role of lactate in sepsis care. We provide recommendations to aid lactate interpretation in the ED and highlight areas for future research.Copyright © 2019 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.
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