• J Neuroimaging · Apr 2012

    Case Reports

    Atypical Wernicke's encephalopathy showing involvement of substantia nigra.

    • Bhagheerathi Kalidass, Rajani Sunnathkal, Dr Vital Rangashamanna, and Rajesh Paraswani.
    • Department of Radiology, Yashoda Hospital, Hyderabad, Andhra Pradesh, India. bharathi.doctor@gmail.com
    • J Neuroimaging. 2012 Apr 1;22(2):204-7.

    Case HistoryWernicke's encephalopathy is a metabolic disorder caused by deficiency of thiamine (vitamin B1) seen in alcoholics and even in nonalcoholic patients, classically presenting with a triad of ataxia, ophthalmoplegia, and altered mental status. Typical findings in magnetic resonance imaging are represented by symmetric signal alterations in medial thalami, mamillary bodies, tectal plate, and periaqueductal area and atypical findings involve lesions in cerebellum, midline vermis, red nuclei, dentate, caudate, cranial nerve nuclei, splenium and cerebral cortex. We report here a case of nonalcoholic starvation induced atypical WE showing symmetrical lesions in substantia nigra in addition to the classical neuroradiological findings.Copyright © 2010 by the American Society of Neuroimaging.

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