• Hum Vaccin Immunother · Oct 2016

    Ebola vaccines - Where are we?

    • Sara Viksmoen Watle, Gunnstein Norheim, and John-Arne Røttingen.
    • a Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health , Oslo , Norway.
    • Hum Vaccin Immunother. 2016 Oct 2; 12 (10): 2700-2703.

    AbstractThe 2014-16 Ebola outbreak in West Africa has by far been the largest and most devastating Ebola outbreak so far. At the start of the epidemic only 2 Ebola DNA vaccine candidates had been tested in clinical trials and the correlate of protection in humans was unknown. International stakeholders coordinated by the World Health Organization agreed to fast-track the development of 2 Ebola vaccine candidates, based on adenovirus and vesicular stomatitis virus (VSV) vectors. Phase I and II clinical trials were initiated in the autumn of 2014 and found both vaccines to be acceptable for proceeding to phase III trials. Despite the epidemic waning in the spring of 2015, by July 2015 preliminary results from a phase III trial in Guinea proved the Ebola VSV vaccine to be effective.

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