• Annual review of medicine · Jan 2017

    Review

    Toward an Effective Ebola Virus Vaccine.

    • Rohan Keshwara, Reed F Johnson, and Matthias J Schnell.
    • Department of Microbiology and Immunology, Sidney Kimmel Medical College,Thomas Jefferson University, Philadelphia, Pennsylvania 19107; email: Matthias.Schnell@jefferson.edu.
    • Annu. Rev. Med. 2017 Jan 14; 68: 371-386.

    AbstractLong-term control of viral outbreaks requires the use of vaccines to impart acquired resistance and ensuing protection. In the wake of an epidemic, established immunity against a particular disease can limit spread and significantly decrease mortality. Creation of a safe and efficacious vaccine against Ebola virus (EBOV) has proven elusive so far, but various inventive strategies are now being employed to counteract the threat of outbreaks caused by EBOV and related filoviruses. Here, we present a current overview of progress in the field of Ebola virus vaccine development.

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