• Experimental neurology · Oct 2019

    Review

    Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact.

    • Michelle E Schober, Daniela F Requena, T Charles Casper, Amy K Velhorst, Alyssa Lolofie, Katelyn E McFarlane, Taylor E Otto, Cynthia Terry, and John C Gensel.
    • Department of Pediatrics, Division of Critical Care University of Utah, Salt Lake City, UT 84132, United States. Electronic address: michelle.schober@hsc.utah.edu.
    • Exp. Neurol. 2019 Oct 1; 320: 112971.

    AbstractTraumatic brain injury (TBI) is the leading cause of acquired neurologic disability in children, yet specific therapies to treat TBI are lacking. Therapies that decrease the inflammatory response and enhance a reparative immune action may decrease oxidative damage and improve outcomes after TBI. Docosahexaenoic acid (DHA) modulates the immune response to injury in many organs. DHA given in the diet before injury decreased rat pup cognitive impairment, oxidative stress and white matter injury in our developmental TBI model using controlled cortical impact (CCI). Little is known about DHA effects on neuroinflammation in the developing brain. Further, it is not known if DHA given after developmental TBI exerts neuroprotective effects. We hypothesized that acute DHA treatment would decrease oxidative stress and improve cognitive outcome, associated with decreased pro-inflammatory activation of microglia, the brain's resident macrophages.Copyright © 2019 Elsevier Inc. All rights reserved.

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