• Keiko Kurita, Eugenia L Siegler, M Cary Reid, Renee C Maciejewski, and Holly G Prigerson.
• Center for Research on End-of-Life Care, Weill Cornell Medicine, New York, New York, USA; Division of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
• J Pain Symptom Manage. 2018 Aug 1; 56 (2): 259-263.

ContextPatients with advanced cancer often overestimate their time left to live. Those who have heightened awareness of their cognitive and physical deficits at the end of life may have a better prognostic understanding.ObjectivesWe sought to investigate the extent to which patients' self-reports of physical well-being and cognitive function were associated with prognostic understanding.MethodsLogistic regression analyzed data from Coping with Cancer II, a National Cancer Institute-funded study of patients with advanced cancer from nine U.S. cancer clinics. Patients with metastatic cancers who had an oncologist-estimated life expectancy of less than six months and did not have significant cognitive impairment were eligible (N = 300). Trained interviewers administered subsets of the McGill Quality of Life and the Functional Assessment of Cancer Therapy-Cognition, Version 2, to measure physical well-being and cognitive complaints. There were four dichotomous outcomes: acknowledgment of their terminal illness; understanding that their diagnosis was late or end stage; belief that life expectancy was months, not years; and prognostic understanding, which was defined as accurate responses to all three questions. Covariates included age and gender.ResultsWorse patient-reported physical well-being and cognitive function were independently associated with the patient's acknowledgment of his and/or her terminal illness (adjusted odds ratio 0.91; 95% CI = 0.82, 1.00; P = 0.047 and adjusted odds ratio 1.73; 95% CI = 1.17, 2.55; P = 0.006, respectively).ConclusionPatients who reported worse cognitive function and physical well-being were more aware of their terminal illness than those with better cognitive function.Copyright © 2018 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

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