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- T Yotsuyanagi, S Urushidate, K Yokoi, Y Sawada, M Suno, and T Ohkubo.
- Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.
- Burns. 1998 Dec 1; 24 (8): 751-3.
AbstractThe concentration of orally administered sparfloxacin (SPFX), an antimicrobial agent, in exudates from the suture wounds beneath occlusive dressings has been measured. Twenty-one patients who received oral therapy with 100 mg of SPFX prior to surgery and 200 mg/day of SPFX after surgery were studied. During the operations, the suture wounds were covered by occlusive film. 48h post-operation, wound exudates under the dressings were drawn and measured using high performance liquid chromatography. SPFX values were 0.801+/-0.340 microg/ml (mean+/-SD). The results suggest that wound exudates beneath the occlusive dressing have concentrations of SPFX high enough to prevent infection in most cases when administered orally.
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