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- Hollie J Pegram, Eric L Smith, Sarwish Rafiq, and Renier J Brentjens.
- Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Immunotherapy. 2015 Jan 1; 7 (5): 545-61.
AbstractChimeric antigen receptor (CAR) T-cell therapy has recently come into the spotlight due to impressive results in patients with B-cell acute lymphoblastic leukemia. By targeting CD19, a marker expressed most B-cell tumors, as well as normal B cells, CAR T-cell therapy has been investigated as a treatment strategy for B-cell leukemia and lymphoma. This review will discuss the successes of this therapy for the treatment of B-cell acute lymphoblastic leukemia and the challenges to this therapeutic strategy. We will also discuss application of CAR T-cell therapy to chronic lymphocytic leukemia and other B-cell malignancies including a follicular lymphoma, diffuse large B-cell lymphoma, as well as acute and plasma cell malignancies.
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