• Neurotoxicology · Nov 2009

    Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy.

    • Yongmin Chang, Seung-Tae Woo, Jae-Jun Lee, Hui-Jin Song, Hui Joong Lee, Don-Sik Yoo, Suk Hwan Kim, Hun Lee, Young Joo Kwon, Hyung Jin Ahn, Joon-Ho Ahn, Sin-Jae Park, Young Cheol Weon, In-Sung Chung, Kyoung Sook Jeong, and Yangho Kim.
    • Department of Molecular Medicine, Kyungpook National University College of Medicine, Kyungpook National University Hospital, Daegu, South Korea.
    • Neurotoxicology. 2009 Nov 1; 30 (6): 950-7.

    BackgroundOccupational and environmental exposure to manganese (Mn) is associated with various neurobehavioral and movement dysfunctions. However, few studies have systemically examined the neurochemical effects of Mn exposure.ObjectivesWe examined typical changes in cerebral metabolite ratios in welders chronically exposed to Mn, compared with control individuals, using proton magnetic resonance spectroscopy (MRS), investigated whether an abnormality in brain metabolism is associated with neurobehavioral changes, and assessed possible implications of chronic Mn exposure.MethodsThirty-five welders chronically exposed to Mn and 20 age-matched healthy subjects underwent single-voxel MRS at short echo time to assess the N-acetylaspartate (NAA), myoinositol (mI), total choline (tCho), and glutamine plus glutamate (Glx) levels, each of which was expressed as a ratio to total creatine (tCr). Neurobehavioral tests were also performed to define cognitive status.ResultsNAA/tCr, Glx/tCr, and tCho/tCr ratios in the frontal gray matter (anterior cingulate cortex; ACC) and parietal white matter did not differ significantly between welders and control subjects. These metabolite ratios did not correlate significantly with blood Mn concentration or neurobehavioral parameters. However, mI levels in the ACC, but not in the parietal white matter, were significantly reduced in welders compared with control individuals (P<0.01). Furthermore, in the frontal lobe of the brain, the mI/tCr ratio was significantly correlated with verbal memory scores as well as blood Mn concentration (P<0.05).ConclusionsThe cognitive decline observed in welders exposed to Mn was associated with a decreased mI/tCr ratio in the ACC. The depletion of mI in welders may reflect possible glial cell swelling and/or detoxification processes associated with long-term exposure to Mn.

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