• Pallavi Bedi, James D Chalmers, Pieter C Goeminne, Cindy Mai, Pira Saravanamuthu, Prasad Palani Velu, Manjit K Cartlidge, Michael R Loebinger, Joe Jacob, Faisal Kamal, Nicola Schembri, Stefano Aliberti, Uta Hill, Mike Harrison, Christopher Johnson, Nicholas Screaton, Charles Haworth, Eva Polverino, Edmundo Rosales, Antoni Torres, Michael N Benegas, Adriano G Rossi, Dilip Patel, and Adam T Hill.
• MRC Center for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK. Electronic address: drpallavibedi@gmail.com.
• Chest. 2018 May 1; 153 (5): 1177-1186.

ObjectivesThe goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.MethodsThe Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients.ResultsA total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV1, sputum purulence, and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operating-characteristic curve values for BRICS in the derivation cohort were 0.79 for percent predicted FEV1, 0.71 for sputum purulence, and 0.75 for hospital admissions per year; these values were 0.81, 0.70, and 0.70, respectively, in the validation cohort. Sputum free neutrophil elastase activity was significantly elevated in the group with emphysema on CT imaging.ConclusionsA simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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