• Psychiatry research · Feb 1996

    Comparative Study Clinical Trial Controlled Clinical Trial

    Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: a study with ondansetron.

    • L N Yatham, A P Zis, R W Lam, M Srisurapanont, K McGarvey, and O Agbayewa.
    • Department of Psychiatry, University of British Columbia, Vancouver, Canada.
    • Psychiatry Res. 1996 Feb 28; 60 (1): 33-9.

    AbstractThe effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to attenuate ECT-induced PRL release suggested that serotonin3 receptors are not involved in mediating this response.

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