Monoclonal Antibodies Hypersensitivity: Prevalence and

Immunol Allergy Clin North Am · Nov 2017

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Monoclonal Antibodies Hypersensitivity: Prevalence and Management.

The use of monoclonal antibodies (mAbs) has become broader because of their recognized effectiveness in the treatment of autoimmune, neoplastic, and inflammatory diseases. Consequently, hypersensitivity reactions (HSR) secondary to mAbs are being reported more often, and each mAb-related HSR presents specific features. This article discusses the main biological agents and associated HSR, the clinical presentation of such reactions, and the role of tryptase and skin testing in the diagnosis. Rapid drug desensitization procedures to mAbs enable selected allergic patients to receive full therapeutic doses in a safe manner and are also discussed.

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- Rafael Bonamichi Santos and Violeta Régnier Galvão.
- Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, Av. Dr. Arnaldo, 455-Cerqueira César, São Paulo, São Paulo 01246-903, Brazil.
- Immunol Allergy Clin North Am. 2017 Nov 1; 37 (4): 695-711.
AbstractThe use of monoclonal antibodies (mAbs) has become broader because of their recognized effectiveness in the treatment of autoimmune, neoplastic, and inflammatory diseases. Consequently, hypersensitivity reactions (HSR) secondary to mAbs are being reported more often, and each mAb-related HSR presents specific features. This article discusses the main biological agents and associated HSR, the clinical presentation of such reactions, and the role of tryptase and skin testing in the diagnosis. Rapid drug desensitization procedures to mAbs enable selected allergic patients to receive full therapeutic doses in a safe manner and are also discussed.Copyright © 2017 Elsevier Inc. All rights reserved.

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