• Korkut Bostanci, Alper Toker, Yusuf Bayrak, Sukru Dilege, Gulcin Aykac-Toker, Mert Senturk, and Mehmet Tugrul.
• Department of Thoracic Surgery, Istanbul School of Medicine, Istanbul University, 81090 Kozyataği, Istanbul, Turkey.
• J. Cardiothorac. Vasc. Anesth. 2003 Dec 1; 17 (6): 721-4.

ObjectiveTo investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung.DesignExperimental study.SettingsUniversity hospital.ParticipantsThirty Wistar rats.InterventionsIn experimental group 1 (G-I) (n = 5) 20 mg/L, in G-II (n = 5) 100 mg/L, in G-III (n = 5) 400 mg/L, and in G-IV (n = 5) 1000 mg/L of theophylline was added to modified Euro-Collins solution and perfused the lungs. Lungs were extracted without an ischemic period in control group 1 (C-I) and perfused with modified Euro-Collins solution in control group 2 (C-II). Lungs were kept in a hypothermic state for 6 hours and then ventilated for 30 minutes with 100% O(2).Measurements And Main ResultsTissue levels of dien congugate (DC) and malonylaldehyde (MDA) were measured. Comparison of 6 groups revealed statistically significant differences for DC and MDA (p < 0.0001 for both comparisons). Both DC and MDA levels of C-II were found to be higher than G-III and G-IV (p = 0.008). DC and MDA levels of G-III and G-IV were significantly lower than G-I and G-II (p = 0.008 for all comparisons).ConclusionThe results of this study showed that 400 mg/L and 1000 mg/L of theophylline added to the modified Euro-Collins solution decreased the intermediate products of lipid peroxidation. Theophylline merits further investigation in ischemia-reperfusion studies as a potentially beneficial agent.

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